| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_941945d77485b24d7f4d253f449c2862
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_672b92109dc0cb1d8839f125c90e1096
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f113c06c2aa2d5435ed38e0a5c2ad61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a135a933620c99beab01d4ac785d25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb378176f015d03f7cd852181149cf05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d50c7e5fb7736cae704eaa90a0edcc97 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 |
| filingDate |
2009-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e9dd316ff501925c9fbe1a302ccfc6b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3c6c5b9a8415f4ac1821ecb787abfdc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26f47583d3fec6a11ddeb32bf9bb9b50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e73e9210275926f421a50dadd3329ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bb99fbe4f5c0a3bdb4ab9131ed453a6 |
| publicationDate |
2013-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8361981-B2 |
| titleOfInvention |
Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| abstract |
Administration of antisense oligodeoxynucleotides (ODN) targeted against the testosterone-repressed prostate message-2 (TRPM-2) gene can reduce the amount of TRPM-2 in renal cell cancer (RCC) cells and other cancer cells, and as a result enhance chemosensitivity of these cells to chemotherapy agents and radiation. Thus, for example, the sensitivity of renal cell cancer cells to a chemotherapeutic agent can be increased by exposing renal cell cancer cells to a chemotherapeutic agent and an agent which reduces the amount of TRPM-2 in the renal cell cancer cells. This provides an improved method for treatment of renal cell cancer, which is generally resistant to treatment with known chemotherapy agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9457045-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9095602-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013017272-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9074209-B2 |
| priorityDate |
2000-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |