| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a135a933620c99beab01d4ac785d25 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate |
2001-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88b2b13cef7726d03d9e07d478f62d64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5a593601dfdb20ea94fe432bb5279de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d00b515e886b5f8615c3e4656dc8ebc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2ca7d1b1c9e8c1b8a01cb031d1e4a01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1df4e2c5722c8dadd3e465518b6971c1 |
| publicationDate |
2009-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7569551-B2 |
| titleOfInvention |
Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| abstract |
Administration of antisense oligodeoxynucleotides (ODN) targeted against the testosterone-repressed prostate message-2 (TRPM-2) gene can reduce the amount of TRPM-2 in renal cell cancer (RCC) cells and other cancer cells, and as a result enhance chemosensitivity of these cells to chemotherapy agents and radiation. Thus, for example, the sensitivity of renal cell cancer cells to a chemotherapeutic agent can be increased by exposing renal cell cancer cells to a chemotherapeutic agent and an agent which reduces the amount of TRPM-2 in the renal cell cancer cells. This provides an improved method for treatment of renal cell cancer, which is generally resistant to treatment with known chemotherapy agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8173615-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8710020-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8361981-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9074209-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9095602-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9512211-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9457045-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8536149-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9200285-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011142827-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008119425-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9822170-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009258089-A1 |
| priorityDate |
2000-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |