http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8263068-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9cfb99aea803bef91440bdfaa259e789 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d5f255445181810a5decc62b0b236f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_483e4e7f159c90445ac72b379fb079f2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P41-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2005-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2c2bf81b883c4055ce43795ad487d25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cefa8517c2035fce7fd1280c59eb7e82 |
| publicationDate | 2012-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8263068-B2 |
| titleOfInvention | Modified cells expressing a protein that modulates activity of bHLH proteins, and uses thereof |
| abstract | The present invention relates to modified cells carrying a heterologous gene sequence encoding a protein, such as an Inhibitor of differentiation (Id) gene sequence that binds a basic helix-loop-helix (bHLH) protein to inhibit cell growth, differentiation and/or tumorigenesis of the modified cells. The modified cells are differentiated, proliferate and do not become tumorigenic when grafted into a recipient subject. Additionally, the modified cells produce a factor or factors that enhance the viability of co-grafted organs, tissues or cells. Thus, the modified cells are useful for testing agents for effects on the cells, for co-grafting with transplant organs, tissues or cells. The modified cells are also useful for enhancing the viability of thawing cells that have been cryo-preserved. In one embodiment, the modified cells are modified Sertoli cells. |
| priorityDate | 2004-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.