| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50135123ba50354d7b10cf6830d48928 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate |
2007-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce671a7b74d2d85441858fcfd78141cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc0c35b83ceb1ae9ff64dccef1319e00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7f2c2525665444adaa2178b8d55bdf1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_682357754986891b729f642c9e6a0d06 |
| publicationDate |
2011-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8039230-B2 |
| titleOfInvention |
Selection of host cells expressing protein at high levels |
| abstract |
The invention provides a DNA molecule comprising an open reading frame sequence that encodes a selectable marker polypeptide, wherein said DNA molecule in the coding strand comprises a translation start sequence for the selectable marker polypeptide having a GTG startcodon or a TTG startcodon, and wherein the open reading frame sequence that encodes the selectable marker protein has been mutated to replace at least half of its CpG dinucleotides as compared to the native open reading frame sequence that encodes the selectable marker protein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011014655-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9376687-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8709765-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865468-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9029137-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8685723-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8440805-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011091977-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8785610-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9228004-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011059495-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8809046-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9783812-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8759615-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8753879-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8771984-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8722359-B2 |
| priorityDate |
2004-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |