| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29c5d94f49a24f38a2b3585bfbc3b9d2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2008-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9165fadb685f878702e27aced45873e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5f05da8e4fd29c564d50b29c4976376
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_924a4f416d84b33af65acfde935798ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8534548779787e9715d583e94ff4c666
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96f2f2fedff431282677e889c3314605 |
| publicationDate |
2011-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7939075-B2 |
| titleOfInvention |
Human monoclonal anti-amyloid-beta antibodies |
| abstract |
Isolated, monoclonal, human, anti-β-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomeric forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21-37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formation and reduce plaque size in vivo and to not bind brain vessel walls. Accordingly, the antibodies are useful in human and veterinary medicine for the treatment and prophylaxis of Alzheimer's disease and other neurodementing diseases. Methods of detecting or measuring the progression of a neurodementing disease also are provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022192636-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286279-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10035823-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10428113-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11028129-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022251048-A1 |
| priorityDate |
2007-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |