| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca32fd2a44fd326ffd027a75a57bd13f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6415 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-33 |
| filingDate |
2004-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b02047f0ae1941c4f5fa17dc8a07d57c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c798102c6ed1536fa6aed755829317be |
| publicationDate |
2011-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7923015-B2 |
| titleOfInvention |
Methods for direct visualization of active synapses |
| abstract |
A method for visualizing an active synapse wherein said method comprises: (a) exposing cells forming the active synapse to a biomarker comprising at least fragment C of tetanus toxin and a reporter protein; and (b) visualizing the biomarker; wherein the accumulation of the biomarker into dendritic spines of the cells allows visualization of an active synapse. Also, a method for screening molecules capable of modulating synapse activity is provided. A kit useful for the early diagnosis of neurodegenerative disease comprises a biomarker comprising at least fragment C of tetanus toxin and a reporter protein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9650606-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011002914-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9267936-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9952204-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9163216-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10160953-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11614437-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10386360-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8835168-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9489474-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10935541-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10266804-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9404140-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8828721-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8815584-B1 |
| priorityDate |
1997-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |