| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ecbc2fe2a2457bf54ab88a6e5032732 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate |
2008-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e0b71c43565231770632bad74bbc8c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1a6642f77cfe6af21f4671198e3a0c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e077386a91a882cf29d8131a2a2c803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcc4fe7739b339a3fdb0e84314c42d6e |
| publicationDate |
2011-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7893244-B2 |
| titleOfInvention |
Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases |
| abstract |
Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10004760-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9771581-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9228189-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4035659-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011124710-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10543232-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11298376-B2 |
| priorityDate |
2005-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |