http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7807416-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b63e00734c7dae2e2dccd070bb2c62cb |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4291 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate | 2008-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5a31f01ec2136bb71829e6b71ac8136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca7fb7ab8adc1bf04f24e9d512727938 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8d3a2e47e9efbbbc147031d75a41096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14be20c6cb37e7a65c2335f1ee79ddcd |
| publicationDate | 2010-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7807416-B2 |
| titleOfInvention | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| abstract | Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the effector function of monoclonal antibodies and monoclonal antibodies with increased effector function. |
| priorityDate | 2003-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.