| abstract |
Compounds comprising n n n n n n n n n n n n or a pharmaceutically acceptable salt or a prodrug thereof; n wherein a dashed line indicates the presence or absence of a bond; n Y is an organic acid group, or an amide or ester thereof comprising from 1 to 12 carbon atoms; or Y is hydroxymethyl or an ether thereof comprising from 1 to 12 carbon atoms; n or Y is a tetrazolyl group; n A is —(CH 2 ) 6 —, cis —CH 2 CH═CH—(CH 2 ) 3 —, or —CH 2 C≡C—(CH 2 ) 3 —, wherein 1 or 2 carbon atoms may be substituted with S or O; or A is —(CH 2 ) m —Ar—(CH 2 ) o — wherein Ar is interarylene or heterointerarylene, the sum of m and o is from 1 to 4, and wherein one CH 2 may be replaced with S or O; n J is CHOH, C═O, CH 2 CHOH, or CH 2 C═O; and n Ar 1 is aryl, heteroaryl, CH 2 -aryl, CH 2 -heteroaryl, O-aryl, O-heteroaryl, S-aryl, or S-heteroaryl. |