| abstract |
Disclosed herein is a compound comprising a formula n n n n n n n n n n or a pharmaceutically acceptable salt or a prodrug or a metabolite thereof;n nY isn n n n n n n n n n n A is —(CH 2 ) 6 —, cis —CH 2 CH═CH—(CH 2 ) 3 —, or —CH 2 C≡C—(CH 2 ) 3 —, wherein 1 or 2 carbon atoms may be substituted with S or O; or A is —(CH 2 ) m —Ar—(CH 2 ) o — wherein Ar is interarylene or heterointerarylene, the sum of m and o is from 1 to 4, and wherein one CH 2 may be substituted with S or O; andn nD is aryl or heteroaryl.n nMethods of use are also disclosed. |