| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a01717442a2a920617ac88dbdf9caacc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2005-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c967aa824c6db740c6c151d397ff0a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b65a0227c9b6801b237a2646b2a07f3c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1c789c822a92734763429662e715ab0 |
| publicationDate |
2010-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7718366-B2 |
| titleOfInvention |
Methods and compositions relating to COL2A1 gene mutations and osteonecrosis |
| abstract |
Methods, compounds, and kits for the diagnosis or screening of osteonecrosis are described, and the development of animal models for COL2A1 function in osteonecrosis is put forth. Novel mutations in the COL2A1 gene are identified that are associated with avascular necrosis of the femoral head. Methods of treatment of osteonecrosis and avascular necrosis of the femoral head, including gene therapy approaches comprising introduction of COL2A1 nucleic acid are contemplated. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10226513-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10709768-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017175963-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101794713-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10532084-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109310731-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109310731-A |
| priorityDate |
2004-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |