Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4245 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 |
filingDate |
2008-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2010-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa96bfedc2342c91c834b615209f2794 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8629f9a3f90719ed6461af49537fb17b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8a54626aa919f8f8fc3a26f069a3a50 |
publicationDate |
2010-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-7691887-B2 |
titleOfInvention |
Triazole derivatives which are SMO antagonists |
abstract |
The present invention provides a method for the treatment or prevention of conditions which can be ameliorated by Smo antagonism, which method comprises administration to a patient in need thereof of an effective amount of a compound of formula I or a composition comprising a compound of formula I: n nor a pharmaceutically acceptable salt or solvate thereof; wherein:n 2 of X, Y and Z represent nitrogen atoms, and the other represents an oxygen atom; R 1 and R 2 are taken together with the atom to which they are attached and represent a cyclobutyl ring, optionally substituted with 1-2 fluorine atoms, and R 3 represents hydrogen or a fluorine atom; or R 1 represents methyl, R 2 represents methyl or a fluorine atom and R 3 represents a fluorine atom. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011183974-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011183989-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11491154-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8470823-B2 |
priorityDate |
2007-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |