| abstract |
A compound of formula (I): n nfor use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NR X or CR X R Y ; if X═NR X then n is 1 or 2 and if X═CR X R Y then n is 1; R X is selected from the group consisting of H, optionally substituted C 1-20 alkyl, C 5-20 aryl, C 3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; R Y is selected from H, hydroxy, amino; or R X and R Y may together form a spiro-C 3-7 cycloalkyl or heterocyclyl group; R C1 and R C2 are independently selected from the group consisting of hydrogen and C 1-4 alkyl, or when X is CR X R Y , R C1 , R C1 , R C2 , R X and R Y , together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; R 1 is selected from H and halo; and Het is selected from:n n nwhere Y 1 is selected from CH and N, Y 2 is selected from CH and N, Y 3 is selected from CH, CF and N, where only one or two of Y 1 , Y 2 and Y 3 can be N; andn n nwhere Q is O or S. |