| abstract |
Novel isoquinoline acetic acids and derivatives thereof oftheformulaeandwherein R is hydrogen or alkyl or 1 to 3 carbon atoms, R<sub>1</sub> is-CH<sub>2</sub>-X or-O-CH<sub>2</sub>-X, R<sub>2</sub> is-CH<sub>2</sub>-X, R, is-X or-CH<sub>2</sub>-X, and R<sub>4</sub> is hydrogen or methyl, wherein X is phenyl or monosubstituted or disubstituted phenyl, said substituents being chloro, bromo or fluoro; are useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications, especially diabetic cataracts. Also disclosed are pharmaceutical compositions containing the novel compounds of this invention and a method of treatment of diabetic cataracts by administration of effective amounts of the novel compounds described herein. |