| abstract |
This invention describes novel pyrazole compounds of formula II: n nwherein Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, and R 2 , R 2′ , R x , and R y are as described in the specification. Ring C has an ortho substituent and is optionally substituted in the non-ortho positions. R 2 and R 2′ are optionally taken together with their intervening atoms to form a fused ring system, such as an indazole ring; and R x and R y are optionally taken together with their intervening atoms to form a fused ring system, such as a quinazoline ring. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3, for treating diseases such as diabetes and Alzheimer's disease. |