| abstract |
(57) Abstract: shows an excellent pharmacological action as well as acts selectively on BZomega 3 receptor, anxiety-related disorders, depression, central diseases such as epilepsy, immune inflammatory diseases, such as certain have arthritis The provision of a medicament useful as a therapeutic or prophylactic agent for the drug. SOLUTION: A pharmaceutical comprising an acetic acid amide derivative represented by the following formula 1 or a physiologically acceptable acid addition salt thereof. Embedded image Wherein, X is -O- or -NR 4 - a, R 1 represents a hydrogen atom, a lower alkyl group, R 2 is a lower alkyl group, an unsubstituted or substituted phenyl group, R 3 is a hydrogen atom, R 4 represents a hydrogen atom, a lower alkyl group or the like; 5 is a hydrogen atom, a lower alkyl group, a hydroxy (lower) alkyl group, etc., R 6 is a hydrogen atom, a lower alkyl group, an unsubstituted or substituted phenyl group, etc., or R 5 and R 6 are taken together as-( CH 2 ) n- (n is 3, 4, 5 or 6), R 7 represents a hydrogen atom, a halogen atom, lower alkoxy and the like, and R 8 represents a hydrogen atom and the like. ] |