| abstract |
The isoquinoline compounds of formula (I) n n nare VR1 antagonists that are useful in treating pain, inflammation, thermal hyperalgesia, urinary incontinence and bladder over activity. The “R”, “Z” and “L” variables are defined in the disclosure and the “X” variables are defined as follows:n X 1 is CR 1 ; X 2 is selected from the group consisting of N and CR 2 ; X 3 is selected from the group consisting of N and CR 3 ; X 4 is CR 4 ; and X 5 is selected from the group consisting of N and C. |