| abstract |
PCT No. PCT/DE85/00275 Sec. 371 Date May 30, 1986 Sec. 102(e) Date May 30, 1986 PCT Filed Aug. 14, 1985 PCT Pub. No. WO86/01204 PCT Pub. Date Feb. 27, 1986.The disclosure relates to novel dopamine derivatives of general Formula I <IMAGE> (I) wherein A is a substituted phenyl residue of the structure <IMAGE> +TR <IMAGE> wherein R1 and R2, being identical or different, mean hydrogen, C1-15-alkyl and allyl, D is <IMAGE> R4 is hydrogen, C1-C4-alkyl, CF3, NH2 E is <IMAGE> X is OH, NH2, <IMAGE> and NH-SO2-CF3, if Y=OH, Y is OH, NH2, <IMAGE> NH-SO2-CF3 and NH-SO2-CH3, if X=OH, but wherein X and Y do not simultaneously mean OH, with R3 being C1-4-alkyl, and Z is H or OH, and, if Z means the hydroxy group, the residue A can also be present in the tautomeric basic form, and their acid addition salts, their preparation, and use as medicinal agents having antihypertensive activity. |