| abstract |
Compounds of the formula n nor a pharmaceutically acceptable salt or isomer thereof, wherein:n Q, X and Z are CH or N; R, R 4 –R 7 and R 13 are H or alkyl; R 1 is H, alkyl, fluoroalkyl, R 9 -arylalkyl, R 9 -heteroarylalkyl, alkyl-SO 2 —, cycloalkyl-SO 2 —, fluoroalkyl-SO 2 —, R 9 -aryl-SO 2 —, R 9 -heteroaryl-SO 2 —, N(R 22 )(R 23 )—SO 2 —, alkyl-C(O)—, cycloalkyl-C(O)—, fluoroalkyl-C(O)—, R 9 -aryl-C(O)—, NH-alkyl-C(O)— or R 9 -aryl-NH—C(O)—; R 2 is H and R 3 is H, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, R 9 -aryl, R 9 -arylalkyl, R 9 -heteroaryl, or R 9 -heteroarylalkyl, and when X and Z are each CH, R 3 is alkoxy, R 9 -aryloxy, R 9 -heteroaryloxy, alkylC(O)O—, alkylaminoC(O)O—, alkylC(O)NR 13 —, alkylOC(O)NR 13 — or alkylaminoC(O)NR 13 —; or R 2 and R 3 together are ═O, ═NOR 10 , ═N—NR 11 R 12 or ═CH-alkyl; R 8 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenymethyl, alpha-substituted benzyl or alpha-substituted heteroarylmethyl; R 9 –R 12 are as defined;n nare disclosed for the treatment of HIV, solid organ transplant rejection, graft v. host disease, inflammatory diseases, atopic dermatitis, asthma, allergies or multiple sclerosis, as well as pharmaceutical compositions and combinations with antiviral or anti-inflammatory agents. |