http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7056928-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
| filingDate | 2002-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c56bd1b4ce711c1ad1678d77c2180cb0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4fdd4b695e761e5acd7b6141185a731 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48c921d9bf6a6c91b35297935a882aa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d303923a711c366f0d141f700250cfa4 |
| publicationDate | 2006-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7056928-B2 |
| titleOfInvention | Pyrimidine derivatives as selective inhibitors of COX-2 |
| abstract | The invention provides the compounds of formula (I) n nand pharmaceutically acceptable salts thereof, in which:n R 1 and R 2 are independently selected from H, or C 1-6 alkyl; R 3 is selected from the group consisting of C 1-6 alkyl, NH 2 and R 6 CONH; R 4 is H or C 1-6 alkyl; R 5 is selected from the group consisting of CH 2 F, CHF 2 , CF 3 CH 2 , CF 3 CHF and CF 3 CF 2 ; A is a 5- or 6-membered aryl, or a 5- or 6-membered aryl substituted by one or more R 7 ; R 6 is selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylOC 1-6 alkyl, phenyl, HO 2 CC 1-6 alkyl, C 1-6 alkylOCOC 1-6 alkyl, C 1-6 alkylOCO, H 2 NC 1-6 alkyl, C 1-6 alkylOCONHC 1-6 alkyl and C 1-6 alkylCONHC 1-6 alkyl; R 7 is selected from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkyl substituted by one or more F, C 1-6 alkoxy, C 1-6 alkoxy substitued by one or more F, SO 2 NH 2 or SO 2 C 1-6 alkyl; and n is 1 to 4. n Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases. |
| priorityDate | 2001-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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