| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-3955
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-244
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6869 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2000-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2006-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8943c1031f44a22766f9b50ff3fa37ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6eaeae024dfa98048dc4fb94741e428d |
| publicationDate |
2006-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7026456-B1 |
| titleOfInvention |
Antibodies against human IL-12 |
| abstract |
The present invention relates to novel p75 heterodimer specific anti-human IL-12 antibodies that are characterized by a higher potency and greater efficacy in neutralizing human IL-12 bioactivity than known heterodimer specific IL-12 monoclonal antibodies. The heterodimer specific antibodies recognize one or more epitopes of the human IL-12 p75 heterodimer, but do not bind to the p40 subunit alone. The heterodimer specific IL-12 antibodies neutralize rhesus monkey IL-12 bioactivity with a potency similar to their potency for neutralizing human IL-12 bioactivity making them useful IL-12 antagonists for in vivo studies in the rhesus monkey. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10413549-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8012475-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012225794-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8716449-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005281823-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11519015-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10765673-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005079177-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11656230-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014234867-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10640803-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7138115-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793915-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007020233-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7534430-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10732182-B2 |
| priorityDate |
1998-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |