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filingDate 1995-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c53d4780f0358f242ba07214060f84f
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publicationDate 1995-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0677533-A2
titleOfInvention Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
abstract Novel methods of obtaining autologous monoclonal antibodies (AMABs) to self-antigens or homologs thereof are disclosed. The method involves genetically engineering a host animal so that it does not biosynthesize at least one epitope of the self-antigen and utilizes the lack of self-tolerance of the host to the epitope to produce antibodies specific to the antigen. The invention also encompasses the AMABs produced by the methods. The invention further encompasses methods of isolating cells by using such AMABs that have specificity for a cell surface antigen.
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