http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7026327-B2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
filingDate | 2002-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2006-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d8eff534b10d2fa306615fbdbfe4ddf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51560fac09f8674af6bc95c85e2f10a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4fdd4b695e761e5acd7b6141185a731 |
publicationDate | 2006-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-7026327-B2 |
titleOfInvention | Pyrimidine derivatives useful as selective COX-2 inhibitors |
abstract | The invention provides the compounds of formula (I) n n nin which:n R 1 is selected from the group consisting of H, C 1-6 alkyl, C 1-2 alkyl substituted by one to five fluorine atoms, C 3-6 alkenyl, C 3-6 alkynyl, C 3-10 cycloalkylC 0-6 alkyl, C 4-12 bridged cycloalkyl, A(CR 4 R 5 ) n and B(CR 4 R 5 ) n ; R 2 is C 1-2 alkyl substituted by one to five fluorine atoms; R 3 is selected from the group consisting of C 1-6 alkyl, NH 2 and R 7 CONH; R 4 and R 5 are independently selected from H or C 1-6 alkyl; A is an unsubstituted 5- or 6-membered heteroaryl or an unsubstituted 6-membered aryl, or a 5- or 6-membered heteroaryl or a 6-membered aryl substituted by one or more R 6 ; R 6 is selected from the group consisting of halogen, C 1-6 alkyl, C 1-6 alkyl substituted by one more fluorine atoms, C 1-6 alkoxy, C 1-6 alkoxy substituted by one or more F, NH 2 SO 2 and C 1-6 alkylSO 2 ; B is selected from the group consisting of n n nwhere n n ndefines the point of attachment of the ring;n R 7 is selected from the group consisting of H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylOC 1-6 alkyl, phenyl, HO 2 CC 1-6 alkyl, C 1-6 alkylOCOC 1-6 alkyl, C 1-6 alkylOCO, H 2 NC 1-6 alkyl, C 1-6 alkylOCONHC 1-6 alkyl and C 1-6 alkylCONHC 1-6 alkyl; and n is 0 to 4. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of variety of conditions and diseases. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006194824-A1 |
priorityDate | 2001-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 442.