http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6977261-B2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05ff905fdc49089f5f25746eaeb40190 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
filingDate | 2003-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2005-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0db4b75046dfdd239da4ee4618d2e574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44d8e22a3325dd01467d166138638db8 |
publicationDate | 2005-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-6977261-B2 |
titleOfInvention | Azaisoquinoline derivatives as matrix metalloproteinase inhibitors |
abstract | This invention provides compounds defined by Formula I n n nor a pharmaceutically acceptable salt thereof,n nwherein R 1 , Q, Y, R 2 , R 3 , R 4 , R 5 , and n are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, as defined in the specification, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of inhibiting an MMP-13 enzyme in an animal, comprising administering to the animal a compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention also provides methods of treating a disease mediated by an MMP-13 enzyme in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides methods of treating diseases such as heart disease, multiple sclerosis, osteo- and rheumatoid arthritis, arthritis other than osteo- or rheumatoid arthritis, cardiac insufficiency, inflammatory bowel disease, heart failure, age-related macular degeneration, chronic obstructive pulmonary disease, asthma, periodontal diseases, psoriasis, atherosclerosis, and osteoporosis in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides combinations, comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with another pharmaceutically active component as described in the specification. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8815894-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8802696-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9034899-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9085531-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9173879-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010292242-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010292243-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010292250-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9498476-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9499531-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9604960-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8741901-B2 |
priorityDate | 2002-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1591.