| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c8fb7e85a6f61273fe3472d4fc675e5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-72 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate |
2000-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2005-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c225d02d52d35f66a2b3891ad90167e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_768cced9f3ccdffec12550b8ba534d3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d2afc7c86948d29b17db9916b6bb93a |
| publicationDate |
2005-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6972319-B1 |
| titleOfInvention |
Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use |
| abstract |
This invention provides novel peptides that function in vivo to stimulate insulin release from pancreatic beta cells in a glucose-dependent fashion. These insulin secretagogue peptides are shown to stimulate insulin release in rat islet cells in vitro, and in vivo. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, in particular type 2 diabetics. In particular, the invention is a polypeptide selected from a specific group of VIP/PACAP-related polypeptides, or functional equivalents thereof. The invention is also directed to a method of treating a metabolic disease in a mammal comprising administering a therapeutically effective amount of the insulin secretagogue peptides to said mammal. Also disclosed are methods of making the peptides, both recombinant and synthetic. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9694053-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9670261-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10806797-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10253079-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009258826-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9982029-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9789165-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9775904-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9771406-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9758561-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9751926-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9750788-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9745360-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004058870-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7378494-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10758592-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9932381-B2 |
| priorityDate |
1999-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |