| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_785ac2b35073f5a6d251678e6fb31b6f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/H01J49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/H01J49-0031 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/H01J49-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N24-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2000-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c94a75a15d134638cff71217f46373ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cd2a5435e7a15f266f1bd45d1fa7323
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4de16ca7c6a4b3a20a567be701d7e12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4013a5785e6e8ab648c83ef58003e3a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_277d693ecbad27c0d7a6bb69049ac4cf |
| publicationDate |
2004-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6770486-B1 |
| titleOfInvention |
Optimization of ligand affinity for RNA targets using mass spectrometry |
| abstract |
The present invention provides methods for the identification ligand compounds that bind to target molecules such as proteins or structured RNA with as little as millimolar (mM) affinity using mass spectrometry. The methods may be used to determine the mode of binding interaction between two or more of these ligand compounds to the target as well as their relative affinities. Also provided are methods for designing compounds having greater affinity to a target molecule by identifying two or more ligands using mass spectrometry methods of the invention and linking the ligands together to form a novel compound. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004266714-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8642753-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007238688-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007238687-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007238690-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007264661-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007238689-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005014713-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9404114-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010234447-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005095622-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002172967-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865674-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8187893-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004053424-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7919476-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7750142-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7399853-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007231909-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010233815-A1 |
| priorityDate |
2000-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |