Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
filingDate |
2001-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2004-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e421a40bb6560bfd11074ed78df15353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ae20325c041aed6df48530c90f0e6cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a706926c5c3cb30b022a6c04d4365bda |
publicationDate |
2004-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-6740523-B2 |
titleOfInvention |
14-3-3σ arrests the cell cycle |
abstract |
Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a growth arrest, with cells blocked in both the G1 and G2 phases of the cell cycle. The G1 block has been shown to be due to the p53-mediated induction of the cyclin-dependent kinase inhibitor p21<WAF1/CIP1/SDI1>, but the basis for the G2 arrest is unknown. Through a quantitative analysis of gene expression patterns in CRC cell lines, we have discovered that 14-3-3sigma is strongly induced by gamma-irradiation and other DNA-damaging agents. The induction of 14-3-3sigma is mediated by a p53-responsive element located 1.815 kb upstream of its transcription start site. Exogenous introduction of 14-3-3sigma into cycling cells results in a G2 block similar to that observed following irradiation. These results document a molecular mechanism for G2/M control that is regulated in human cells by p53. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1915432-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010085213-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9724430-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006134838-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005181385-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11541027-B2 |
priorityDate |
1997-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |