http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5776676-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a6a9431aa1fe5109ca95ad4e332231b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 1995-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4d66d4e7f0c3e330abb4289f1a7b23c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32b09b4b0d77127501826f58914b0e7c |
| publicationDate | 1998-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5776676-A |
| titleOfInvention | HME1 nucleic acids and probes |
| abstract | A full length cDNA clone from a normal human mammary epithelial cell (strain 184) encoding a 25 kDa protein, HME1, was isolated. Expression of HME1 RNA appears to be limited to epithelial cells. The HME1 sequence shares strong sequence homology with bovine 14-3-3 protein, which is an activator of tyrosine and tryptophan hydroxylase, but the tissue distribution of HME1 differs from that of 14-3-3. Compared with normal mammary epithelial cells, expression of HME1 RNA is dramatically low in cells derived from human mammary carcinoma and in normal mammary epithelial cells transformed by oncogenes. HME1 therefore appears to be a cellular differentiation marker that is down-regulated during neoplastic transformation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9931240-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0065053-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9931240-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6482600-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6335156-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6740523-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0065053-A3 |
| priorityDate | 1992-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.