http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6660530-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0459 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 |
| filingDate | 2001-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8397b69392a13179542321aac02b19a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_650cb9452f980cdf0073959127c8e287 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17c12be9313229965539f18a969dee8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c177b0f0ad424cd3aff2695ff0e0edeb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8912112d60391de942833ffad5db908 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69f2408b8ef06a3c162b1f9b558ea47b |
| publicationDate | 2003-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6660530-B2 |
| titleOfInvention | Methods for labeling β-amyloid plaques and neurofibrillary tangles |
| abstract | A method for labeling beta-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprises contacting a compound of formula (I):with mammalian tissue. In formula (I), R1 is selected from the group consisting of -C(O)-alkyl, -C(O)-alkylenyl-R4, -C(O)O-alkyl, -C(O)O-alkylenyl-R4, -C=C(CN)2-alkyl, -C=C(CN)2-alkylenyl-R4,R4 is a radical selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; R5 is a radical selected from the group consisting of -NH2, -OH, -SH, -NH-alkyl, -NHR4, -NH-alkylenyl-R4, -O-alkyl, -O-alkylenyl-R4, -S-alkyl, and -S-alkylenyl-R4; R6 is a radical selected from the group consisting of -CN, -COOH, -C(O)O-alkyl, -C(O)O-alkylenyl-R4, -C(O)-alkyl, -C(O)-alkylenyl-R4, -C(O)-halogen, -C(O)NH, -C(O)NH-alkyl, -C(O)NH-alkylenyl-R4; R7 is a radical selected from the group consisting of O, NH, and S; and R8 is N, O or S. R2 and R3 are each independently selected from the group consisting of alkyl and alkylenyl-R10, wherein R10 is selected from the group consisting of -OH, -OTs, halogen, spiperone, spiperone ketal and spiperone-3-yl. Alternatively, R2 and R3 together form a heterocyclic ring, optionally substituted with at least one radical selected from the group consisting of alkyl, alkoxy, OH, OTs, halogen, alkylenyl-R10, carbonyl, spiperone, spiperone ketal and spiperone-3-yl. In the compounds of formula (I), one or more of the hydrogen, halogen or carbon atoms can, optionally, be replaced with a radiolabel. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9839699-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006117397-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10357217-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10626083-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7737183-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011286932-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10512699-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009004107-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10377701-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010249418-A1 |
| priorityDate | 1998-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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