| abstract |
A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): n n n n n n n n n n wherein R 1 is a group selected from the group consisting of a halogen substituent, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and hydroxyl group, R 2 is a group selected from the group consisting of a cyano substituent, alkyl substituent with 1 to 4 carbon atoms and halogen substituent, R 3 is a group selected from the group consisting of a hydroxyl group, halogen substituent and substituent represented by the following formula: n n n n n n n n n n (wherein R 4 is a hydrogen, halogen substituent or hydroxyl group, and m is an integer of 1 to 4), provided that at least one of R 1 , R 2 , R 3 and R 4 represents a radioactive halogen, and a reagent comprising the same. |