http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6639072-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9afcdbb9ef9ff258c504f3332f12a427 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-075 |
| filingDate | 2000-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65547b89590f04ceba9fd0c08a582f45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15fd74cd723918a95f5a97c428e6fcea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfbab296723bf3e750f0ec7b63aecac3 |
| publicationDate | 2003-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6639072-B1 |
| titleOfInvention | Process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine |
| abstract | A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3-5-diamine (lamotrigine) of the formula I:2,3-Dichloronitrobenzene in C1-C6 aliphatic alkanol is hydrogenated at 55-90 psi gas pressure using metal catalyst at 27-35° C. 2,3-Dichloroaniline is diazotised and cyano-de-diazonised with metal cyanide at 65-80° C. 2,3-Dichlorobenzonitrile is hydrolysed and 2,3-dichlorobenzoic acid is chlorinated at 55-130° C. Cyano-de-halogenation of 2,3-dichlorobenzoyl chloride is carried out with a metal cyanide and alkali metal iodide by refluxing in an aprotic solvent under an inert atmosphere. 2,3-Dichlorobenzoyl cyanide is condensed with aminoguanidine bicarbonate in an organic solvent in acidic conditions using catalyst at 90-125° C. followed by insitu cyclisation of the Schiff's base by refluxing in an aliphatic alkanol with base. Crude lamotrigine is purified. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005238724-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7390807-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005171107-A1 |
| priorityDate | 2000-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.