| abstract |
Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1)whereinR1 is a binding partner, a linker or H;a and b are 0 or 1, provided that the total of a and b is 0 or 1;A is N or C;X is S, O, -C(O)-, NH or NCH2R6;Y is -C(O)-;Z is taken together with A to form an aryl or heteroaryl ring structure comprising 5 or 6 ring atoms wherein the heteroaryl ring comprises a single O ring heteroatom, a single N ring heteroatom, a single S ring heteroatom, a single O and a single N ring heteroatom separated by a carbon atom, a single S and a single N ring heteroatom separated by a carbon atom, 2 N ring heteroatoms separated by a carbon atom, or 3 N ring heteroatoms at least two of which are separated by a carbon atom, and wherein the aryl or heteroaryl ring carbon atoms are unsubstituted with other than H or at least 1 nonbridging ring carbon atom is substituted with R6 or =O;R6 is independently H, C1-C6 alkyl, C2-C6 alkeny, C2-C6 alkynyl, NO2, N(R3)2, C=N or halo, or an R6 is taken together with an adjacent R6 to complete a ring containing 5 or 6 ring atoms;,R3 is a protecting group or H; and tautomers, solvates and salts thereof;and provided that where a is 0, b is 1, and R1 is in whichD2 is independently hydroxyl, blocked hydroxyl, mono, di or triphosphate, or an oligodeoxyribonucleotide otherwise containing only the bases A, G, T and C; andD3 is H or OH;then Z is not unsubstituted phenyl.Also provided are novel intermediates and methods for the preparation and use of the structure (1) compounds. |