| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5e07888f923b7443f3b8eb913614893 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-66 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-625
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 |
| filingDate |
1999-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff05c27a842ad52eda1a661f4fe32704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a46969765359392f6d352b9fb076f988
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_206c79f98a466760d09cd60c58fdf31d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e03dfbfbc695eb92e018c8bd1f9d3ed |
| publicationDate |
2002-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6500651-B1 |
| titleOfInvention |
Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid |
| abstract |
A method for producing mevinolin by a microorganism in a fermentation process having a seed culture stage and a main fermentation stage, includinga) cultivating a microorganism biomass in the seed culture stage to produce an inoculum;b) transferring the inoculum into a fermentation medium in the main fermentation stage; and,c) maintaining steady stage conditions in the main fermentation stage, thereby producing a fermentation broth containing mevinolin. Preferably, the steady state conditions are maintained in the main fermentation stage by one or more of feeding of organic carbon sources; controlling glucose and/or total reducing sugar content; feeding of organic nitrogen sources; controlling pH; controlling foam level; controlling the mass of the fermentation broth by withdrawals and feedings; and, controlling the dissolved oxygen level. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8592191-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008064076-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9976158-B2 |
| priorityDate |
1998-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |