| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ff13f07d8f87ffa7dd2df3976944059 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-62 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 |
| filingDate |
1999-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_874bef73c639b00a14978e8bb295dbf8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1260d0d3d28d56a6146830057e45dbc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd66c15bacfd7246afc3a10e2d29867d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f72448034c290cbc4ea179e25ef27d1 |
| publicationDate |
2001-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6197560-B1 |
| titleOfInvention |
Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid |
| abstract |
A method for producing lovastatin by a microorganism in a fermentation process having a seed culture stage and a main fermentation stage, includinga) cultivating a microorganism biomass in the seed culture stage to produce an inoculum;b) transferring the inoculum into a fermentation medium in the main fermentation stage; and,c) maintaining steady stage conditions in the main fermentation stage, thereby producing a fermentation broth containing lovastatin. Preferably, the steady state conditions are maintained in the main fermentation stage by one or more of feeding of organic carbon sources; controlling glucose and/or total reducing sugar content; feeding of organic and/or inorganic nitrogen sources; controlling pH; controlling foam level; controlling the mass of the fermentation broth by withdrawals and feedings; and, controlling the dissolved oxygen level. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003194394-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014147355-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8715716-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6500651-B1 |
| priorityDate |
1998-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |