| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfd617dc43a4c986d2dd81e4cb39d9dd |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-20 |
| filingDate |
2000-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58aaad7a932697f7ae4cca0c7873191c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_684b3a02002ad5e3cfa008d6cfdcef42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8e77864b398babd1372047e1893f35d |
| publicationDate |
2002-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6337400-B1 |
| titleOfInvention |
Process for the preparation of tetrahydroindolizines |
| abstract |
Described is a process for the preparation of Compound (7) in accordance with the following reaction scheme by reacting Compound (5) with ethylene glycol in a solvent in the presence of a Lewis acid, thereby obtaining Compound (6), and then reacting the resulting compound with a carbonate diester in a solvent in the presence of a metal alkoxide (R1, R6 each represents a C1-6 alkyl group or the like and R5 represents H or C1-5 alkyl group).Compound (7) so obtained is useful as an intermediate for camptothecins useful as antitumor agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11555019-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11634508-B2 |
| priorityDate |
1996-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |