http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6258779-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-827 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-828 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1741 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4747 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 1999-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6eefc79fae6ca93086f3358f3e7c09d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f10a6dac8a90d5933004976c86173a83 |
| publicationDate | 2001-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6258779-B1 |
| titleOfInvention | Method of using fetuin to induce apoptosis in cancer cells |
| abstract | The present invention provides the methods to isolate the proteins specifically induced apoptosis (programmed cell death) in prostate cancer cells (LNCAP), leukemia cells (HL-60), and breast cancer cells (MCF-70), but without effect in normal human lung fibroblast cells (CCD 39 Lu). P-1 has no effect on breast cancer cells. Five proteins have been isolated from the conditioned media of culture cells: (1) Apogen P-1: the proteins (Apogen P-1a, Apogen P-1b and Apogen P-1c) isolated from the conditioned medium of XC cells are able to induce apoptosis in prostate cancer cells (LNCAP) without effect in normal human lung fibroblast (CCD 39 Lu), colon cancer (T84), breast cancer (MCF-7) and leukemia (HL-60) cells. (2) Apogen P-2: the protein isolated from the conditioned medium of C3H1OT1/2 cells is able to induce apoptosis in prostate cancer cells (LNCAP) and breast cancer (MCF-7) without effect in normal human lung fibroblast (CCD 39 Lu) and colon cancer (T84) cells. (3) Apogen L: the protein isolated from the conditioned medium of XC cells is able to induce apoptosis in leukemia cells (HL-60), and breast cancer (MCF-7) without effect in normal human lung fibroblast (CCD 39 Lu), colon cancer (T84) and prostate cancer (LNCAP) cells. The isolated protein Apogen P-2 is at least in part comprised of bovine fetuin. When properly prepared, fetuin is able to induce apoptosis in leukemia cells (HL-60), prostate cancer (LNCaP and PC-3) cells, colon cancer (Colo 205) cells, breast cancer (MCF-7) cells, and lung cancer (Calu-1) cells. The in vivo tests done with fetuin have shown an increased life span for mice bearing leukemia. The invention may lead to the discovery of a novel class of anticancer drug that aims at prostate cancer, breast cancer, leukemia and other cancers by inducing apoptosis in cancer cells without affecting normal cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007004617-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2210606-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03057922-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7232893-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006275838-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8618136-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8034831-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003044400-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7528108-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010011533-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005036994-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005266531-A1 |
| priorityDate | 1997-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.