| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed28726de9f916f355f8adc331e736b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1063 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-24 |
| filingDate |
1994-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e91f6ea21e6e47650eb50ddbe26b32f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faab9ceb8cc7fe696927b4d97009c21b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b028024045fb2100658732aba8c99756
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60080b4fd5781b88bfd1ea1f6de1c383 |
| publicationDate |
2001-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6241986-B1 |
| titleOfInvention |
Human monoclonal antibodies to the CD4-binding domain of HIV, uses thereof and synergistic neutralization of HIV |
| abstract |
Human monoclonal antibodies specific for the CD4-binding domain of HIV gp120 are useful in the neutralization of HIV and in the prevention of HIV infection and the treatment of a subject infected with HIV. Such antibodies and heterohybridomas producing them are disclosed. Synergistic mixtures of at least two human monoclonal antibodies specific for two different epitopes of gp120 are used to neutralize HIV, to prevent HIV infection and to treat a subject infected with HIV. In this synergistic mixture, one antibody has broad HIV group specificity, and is preferably specific for the CD4-binding domain. The other antibody is preferably specific for the V3 loop and has a range of neutralizing activity such that it neutralizes virus of the MN strain, MN-like families, and widely divergent HIV-1 isolates which are members of various V3 lop classes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2848937-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012170765-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2679596-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7482000-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3067368-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10273291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3069730-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3187585-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3072901-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005226874-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2586461-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2599791-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2568289-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2873423-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012154311-A3 |
| priorityDate |
1991-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |