| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dde681bc02e2b3b5743e86deb5eccb6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa1c1d87ed574117d3c3a68814d59172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b8769c0c0163f71ca70b2a2846cd19f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_083c3929b391d2cebac269c294a75d84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_888800e78c92428dbcbb176a6a6715b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4a72c1335968407909f5ebb88211ad0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_970656a7ee20164fb6b6b28b3335d42a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c4322cb4de342be2dbedcbe0c278f6f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56988
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 |
| filingDate |
2012-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ee5ee2276750615bd8ed5113b121c09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5408fd9558fd30648b09b3303513fc48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ab297e9bd270a03ba8131532d299659
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60965d47bb6f5dd7cc739b7bcccc578e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea3ed7cf130c838165c6cd4b4804744b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d70c1ebf5742f9999821e61ac8034c0 |
| publicationDate |
2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10273291-B2 |
| titleOfInvention |
Focused evolution of HIV-1 neutralizing antibodies revealed by crystal structures and deep sequencing |
| abstract |
Antibody VRC01 represents a human immunoglobulin that neutralizes—˜90% of diverse HIV-1 isolates. To understand how such broadly neutralizing HIV-1 antibodies develop and recognize the viral envelope, we used X-ray crystallography and 454 pyrosequencing to characterize additional antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding of different antibodies to the same CD4-binding-site epitope. Antibody recognition was achieved through the evolution of complementary contact domains that were generated in diverse ways. Phylogenetic analysis of expressed heavy and light chains determined by deep sequencing revealed a common pathway of antibody heavy chain maturation confined to IGHV1-2*02 lineage that could pair with different light chains. The maturation pathway inferred by antibodyomics reveals that diverse antibodies evolve to a highly affinity-matured state to recognize an invariant viral structure, providing insight into the development and evolution of broadly neutralizing HIV-1 immunity. |
| priorityDate |
2011-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |