| abstract |
The present invention concerns novel compounds of formula (I). n wherein R 1 is C 1-10 alkyl, C 3-7 cycloalkyl or C 1-6 alkyl substituted with C 3-7 cycloalkyl; R 2 is hydrogen or C 1-6 alkyl; Alk represents C 1-3 alkanediyl; —A— represents a bivalent radical of formula —CH═CH—N═CH— (a), —N═CH—N═CH— (b), —CH═N—N═CH— (c), —CH═CH—CH═N— (d); in said bivalent radicals a hydrogen atom may be replaced by C 1-6 alkyl; and Ar is unsubstituted phenyl; phenyl substituted with up to two substituents selected from halo, C 1-6 alkyl or C 1—6 alkyloxy; unsubstituted naphthyl; or naphthyl substituted with up to two substituents selected from halo, C 1-6 alkyl or C 1-6 alkyloxy; the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof. The present invention further comprises the pharmaceutical compositions comprising compounds of formula (I), the preparation thereof as well as the use as a medicine in the treatment of hyperlipidemia. |