| abstract |
Novel 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1 H -azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones of formulan wherein Q is N or CH; R is hydrogen, C₁₋₆alkyl or arylC₁₋₆alkyl; and R¹ is hydrogen, C₁₋₆alkyl or arylC₁₋₆alkyl; wherein aryl is phenyl optionally substituted with up to 3 substituents each independently selected from halo, C₁₋₆alkyl, C₁₋₆alkyloxy and trifluoromethyl, the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-microbial agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions. |