| abstract |
Tetrahydroisoquinoline 3-carboxamide derivatives of formulaand pharmaceutically acceptable salts thereof wherein:X is(a) CH2;(b) S(c) O; or(d) C(CH3)2;R1 and R2 are independently(a) hydrogen;(b) hydroxy;(c) alkyl;(d) alkoxy;(e) aralkoxy; or(f) halogen.Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance. |