http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005203031-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2caaba601fd6460c7b37706d920d42e2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-22 |
| filingDate | 2005-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6ae450ab068678d8b19c45295af00dc |
| publicationDate | 2005-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005203031-A1 |
| titleOfInvention | Novel antidiabetic agents |
| abstract | Compounds which are 1-(2′-aminoacyl)-2-cyanopyrrolidine derivatives according to general formula (1) are DP-IV inhibitors for treatment of impaired glucose tolerance or type 2 diabetes; wherein A is selected from groups (2, 3 and 4); X is selected from aminoacyl groups corresponding to the natural amino acids, acyl groups R 3 CO, groups R 4 COOC(R 5 )(R 6 )OCO, methoxycarbonyl, ethoxycarbonyl and benzyloxycarbonyl; R 1 is selected from H, C 1 -C 6 alkyl residues, (CH 2 ) a NHW 1 , (CH 2 ) b COW 2 , (CH 2 ) c OW 3 , CH(Me)OW 4 , (CH 2 ) d —C 6 H 4 —W 5 and (CH 2 ) e SW 6 , where a is 2-5, b is 1-4, c is 1-2, d is 1-2, e is 1-3, W 1 is COW 6 , CO 2 W 6 or SO 2 W 6 , W 2 is OH, NH 2 , OW 6 or NHW 6 , W 3 is H or W 6 , W 4 is H or W 6 , W 5 is H, OH or OMe, and W 6 is C 1 -C 6 alkyl, optionally substituted phenyl, optionally substituted heteroaryl or benzyl and R 2 is selected from H and (CH 2 ) n —C 5 H 3 N—Y, where n is 2-4 and Y is H, F, Cl, NO 2 or CN, or R 1 and R 2 together are —(CH 2 ) p — where p is 3 or 4; R 3 is selected from H, C 1 -C 6 alkyl and phenyl; R 4 is selected from H, C 1 -C 6 alkyl, benzyl and optionally substitued phenyl; R 5 and R 6 are each independently selected from H and C 1 -C 6 alkyl or together are —(CH 2 ) m —, where m is 4-6; R 7 is selected from pyridyl and optionally substituted phenyl; R 8 is selected from H and C 1 -C 3 alkyl; and R 9 is selected from H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy and phenyl. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11400072-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10772865-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8076330-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10555929-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11253508-B2 |
| priorityDate | 1999-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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