| abstract |
PCT No. PCT/EP96/02889 Sec. 371 Date Dec. 17, 1997 Sec. 102(e) Date Dec. 17, 1997 PCT Filed Jul. 2, 1996 PCT Pub. No. WO97/03067 PCT Pub. Date Jan. 30, 1997Substituted piperazine compounds of formula I in which HET is a substituted pyrazole, imidazole or 1,2,4-triazole have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, Parkinson's disease, obesity, hypertension, Tourette's syndrome, sexual dysfunction, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, senile dementia, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders and anorexia, cardiovascular and cerebrovascular disorders, non-insulin dependent diabetes mellitus, hyperglycaemia, constipation, arrhythmia, disorders of the neuroendocrine system, stress, prostatic hypertrophy, and spasticity. |