| abstract |
PCT No. PCT/JP97/04526 Sec. 371 Date May 28, 1999 Sec. 102(e) Date May 28, 1999 PCT Filed Dec. 10, 1997 PCT Pub. No. WO98/25915 PCT Pub. Date Jun. 18, 1998A compound, pharmaceutically acceptable salt thereof, or hydrate thereof having a PGD2-antagonistic activity, and an inhibitory activity against infiltration of eosinophils, useful for treating mast cell dysfunction-associated diseases, such as systemic mastocytosis and disorder of systemic mast cell activation, as well as tracheal contraction, asthma, allergic rhinitis, allergic conjunctivitis, urticaria, ischemic reperfusion injury, inflammation and atopic dermatitis, which is shown by the formula (I): is provided. |