| abstract |
A novel 13-aza-14-oxo-TXA2 analogue of general formula: <IMAGE> (III) wherein symbol A represents -CH2CH2-(CH2)m-, cis-CH=CH-(CH2)m-, -CH2O-(CH2)m-, -S-(CH2)m- <IMAGE> R2 represents a bond or a straight or branched alkylene or alkenylene group of from 1 to 10 carbon atom(s) unsubstituted or substituted; R3 represents (i) a phenyl, phenoxy or phenylthio group unsubstituted or substituted, (ii) a straight or branched alkyl, alkenyl or alkynyl group of from 1 to 6 carbon atom(s) unsubstituted or substituted, (iii) a cycloalkyl, cycloalkyloxy or cycloalkylthio group of from 4 to 7 carbon atoms unsubstituted or substituted, (iv) a naphthyl, indolyl or indanyl group, or (v) an amino group unsubstituted or substituted R4 represents a hydrogen atom or a methyl group. |