| abstract |
PCT No. PCT/US96/09495 Sec. 371 Date Dec. 3, 1997 Sec. 102(e) Date Dec. 3, 1997 PCT Filed Jun. 5, 1996 PCT Pub. No. WO96/39178 PCT Pub. Date Dec. 12, 1996A replication defective recombinant adenovirus is provided which contains a complete deletion of its E1 gene and at least a partial deletion of its E3 gene, said virus containing in the site of the E1 deletion a sequence comprising a non-adenovirus promoter directing the replication and expression of DNA encoding a heterologous protein from a disease-causing agent, which, when administered to a mammal in said recombinant virus, elicits a substantially complete protective immune response against the agent. Pharmaceutical and veterinary products containing the recombinant adenovirus are provided. |