| abstract |
PCT No. PCT/AU96/00015 Sec. 371 Date Sep. 25, 1997 Sec. 102(e) Date Sep. 25, 1997 PCT Filed Jan. 15, 1996 PCT Pub. No. WO96/22303 PCT Pub. Date Jul. 25, 1996A methotrexate conjugated to 1-3 acyl groups derived from fatty acids. In particular the invention relates to altering the pharmacokinetic profile and mode of delivery of methotrexate by conjugating it to 1.2 or 3 acyl derivatives of fatty acids. |