abstract |
DRUG LIPID CONJUGATES REPRESENTED BY THE FORMULAS R1-O-CH2-CH(-O-R2)-CH2-O-R3, D1<(-O-CH2-CH(-CH2-O-R4)- O-), R5-O-CH2-CH(-O-R6)-COO-D2 IN THE FORMULAS, R1, R2 AND R3 EACH IS HYDROGEN, FATTY ACYL -CO-D3 OR-D4, WHEREIN D3 AND D4 AREREMAINDERS OF DRUG MOIETIES, AND ONE OF SAID R1, R2 AND R3 IS -CO-D3 OR-D4 AND AT LEAST ONE OTHER OF SAID R1, R2 AND R3 IS FATTY ACYL; R4 IS HYDROGEN OR FATTY ACYL; R5 AND R6 EACH IS HYDROGEN OR FATTY ACYL, AND AT LEAST ONE OF SAID R5 AND R6 IS FATTY ACYL; AND D1 AND D2 ARE REMAINDERS OF DRUG MOIETIES. THESE VOMPOUNDS EXHIBIT THE PHARMACEUTICAL UTILITIES OF THE PARENT DRUGS BUT HAVE ENHANCED AND PROLONGED ACTIVITY WHEN ORALLY ADMINISTERED. |