abstract |
The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R 1 is N-pyrrolidinyl or N-piperidinyl; n R 2 and R 3 are independently hydrogen, --CO--(C 10 -C 22 alkyl), --CO--(C 10 -C 22 branched alkyl), --CO--(C 10 -C 22 alkenyl), --CO--(C 10 -C 22 polyalkenyl), --CO--(C 10 -C 22 alkynyl), or --CO--(CH 2 ) n COR 4 ; provided R 2 and R 3 are not both dodecanoyl, and one of R 2 or R 3 is not hydrogen n R 4 is -3-cholesteryl or --O(CH 2 ) 2 (OR 5 )CH 2 OR 6 ; n R 5 and R 6 are independently hydrogen, --CO--(C 10 -C 22 alkyl), --CO--(C 10 -C 22 branched alkyl), --CO--(C 10 -C 22 alkenyl), --CO--(C 10 -C 22 polyalkenyl), or --CO--(C 10 -C 22 alkynyl); provided one of R 5 or R 6 is not hydrogen; n n is 0-4; and pharmaceutically acceptable salts and solvates thereof, and further provides pharmaceutical compositions containing compounds of formula I, and the use of such compounds. |