| abstract |
The invention provides novel benzothiophenes of the formula (I): <IMAGE> (I) wherein R1 is N-pyrrolidinyl or N-piperidinyl; R2 and R3 are independently hydrogen, -CO-(C10-C22 alkyl), -CO-(C10-C22 branched alkyl), -CO-(C10-C22 alkenyl), -CO-(C10-C22 polyalkenyl), -CO-(C10-C22 alkynyl), or -CO-(CH2)nCOR4; provided R2 and R3 are not both dodecanoyl, and one of R2 or R3 is not hydrogen R4 is -3-cholesteryl or -O(CH2)2(OR5)CH2OR6; R5 and R6 are independently hydrogen, -CO-(C10-C22 alkyl), -CO-(C10-C22 branched alkyl), -CO-(C10-C22 alkenyl), -CO-(C10-C22 polyalkenyl), or -CO-(C10-C22 alkynyl); provided one of R5 or R6 is not hydrogen; n is 0-4; and pharmaceutically acceptable salts and solvates thereof. The present invention further provides pharmaceutical compositions containing compounds of formula I, and the use of such compounds. |